Towards a total human protein map

Towards an Integrated Protein-protein Interaction Map

As protein-protein interaction plays a major role in most cellular processes, identifying the full repertoire of interacting protein pairs in the cell is of great importance. This challenge has been addressed both experimentally and computationally. Large-scale experimental studies provide data sets of interacting proteins. These data sets, while only partial and noisy, allow us to characterize...

A Road Map for Civil Engineers towards Bridge Engineering Through Academic Education and Professional Training

It is common in many countries that engineers having an academic degree in Civil Engineering are appointed responsible for different tasks related to Bridge Engineering. However, there are serious questions about whether formal university courses in civil engineering could cover the needs of a bridge engineer to fulfill his or her job successfully. Regarding the recent significant advances in t...

Towards a comprehensive human protein-protein interaction network

A map of 75 human ribosomal protein genes.

We mapped 75 genes that collectively encode >90% of the proteins found in human ribosomes. Because localization of ribosomal protein genes (rp genes) is complicated by the existence of processed pseudogenes, multiple strategies were devised to identify PCR-detectable sequence-tagged sites (STSs) at introns. In some cases we exploited specific, pre-existing information about the intron/exon stru...

Crawling towards a map of the brain

State-of-the-art techniques reveal a simple circuit of neurons controls the muscle contractions that allow fruit fly larvae to crawl.